Experimental Liver Necrosis

The results outlined in this communication constitute a partial report of a somewhat comprehensive investigation s now in progress of the chemical processes concerned in the variations occurring in the amounts of fats and lipoids in the hepatic cell under normal and various pathological conditions. It has seemed advisable, in connection with the other investigations of liver necrosis here presented, to discuss at this time only that part of the general study which deals with the fatty changes in hepatic necrosis brought about by the injection of h~emotoxic imnmne serum. The study of such lesions is of peculiar value in view of the attempts which have been made to bring into a relation of cause and effect the autolysis of the organ and the appearance of the fat. We have therefore with this point in view attempted to determine whether in the necrosis (autolysis) which follows the injection of the serum there occurs any alteration in the fat content correspond-